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| First Round Draft Pick History |
| 1 | 14 | 14 | 2010 | Annual Draft | RP | Luke | Gregerson | MLB |
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| 1 | 27 | 27 | 2009 | Annual Draft | 3B | Dayan | Viciedo | OS |
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| Complete Draft History |
| 1 | 14 | 14 | 2010 | Annual Draft | RP | Luke | Gregerson | MLB |
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| 2 | 14 | 42 | 2010 | Annual Draft | OF | Tony | Gwynn | MLB |
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| 3 | 14 | 70 | 2010 | Annual Draft | SP | JD | Martin | MLB |
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| 4 | 14 | 98 | 2010 | Annual Draft | SS | Ramiro | Pena | MLB |
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| 5 | 14 | 126 | 2010 | Annual Draft | OF | Jeff | Fiorentino | MLB |
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| 6 | 14 | 154 | 2010 | Annual Draft | OF | Luis | Durango | MLB |
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| 7 | 14 | 182 | 2010 | Annual Draft | C | Jose | Lobaton | MLB |
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| 8 | 14 | 210 | 2010 | Annual Draft | 1B | Kevin | Barker | MLB |
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| 9 | 14 | 238 | 2010 | Annual Draft | RP | Marco | Estrada | MLB |
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| 10 | 14 | 266 | 2010 | Annual Draft | SP | Anthony | Ortega | MLB |
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| 11 | 14 | 294 | 2010 | Annual Draft | SP | Armando | Gabino | MLB |
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| 12 | 14 | 322 | 2010 | Annual Draft | SP | Wilton | Lopez | MLB |
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| 13 | 14 | 350 | 2010 | Annual Draft | SP | Edgar | Osuna | MIN |
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| 14 | 14 | 378 | 2010 | Annual Draft | SP | Carlos | Monasterios | MIN |
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| 15 | 14 | 406 | 2010 | Annual Draft | SP | Kenneth | Herndon | MIN |
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| 1 | 27 | 27 | 2009 | Annual Draft | 3B | Dayan | Viciedo | OS |
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| 2 | 27 | 55 | 2009 | Annual Draft | C | Steve | Holm | MLB |
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| 3 | 27 | 83 | 2009 | Annual Draft | SS | Sean | Kazmar | MLB |
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| 4 | 27 | 111 | 2009 | Annual Draft | OF | Mitch | Maier | MLB |
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| 5 | 27 | 139 | 2009 | Annual Draft | OF | Lou | Montanez | MLB |
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| 7 | 27 | 195 | 2009 | Annual Draft | SP | Dirk | Hayhurst | MLB |
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| 8 | 27 | 223 | 2009 | Annual Draft | SS | Ivan | Ochoa | MLB |
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| 9 | 27 | 251 | 2009 | Annual Draft | C | Michel | Hernandez | MLB |
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| 10 | 27 | 279 | 2009 | Annual Draft | SS | Edwin | Maysonet | MLB |
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| 11 | 27 | 307 | 2009 | Annual Draft | 3B | Ryan | Rohlinger | MLB |
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| 12 | 27 | 335 | 2009 | Annual Draft | 2B | Doug | Bernier | MLB |
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